| Terms |
Syn/Abv |
Defition |
| Stem cell |
SC |
A cell from wich all committed blood cells arise |
| Hematopietic teme cell transplantation |
HSCT |
A procedure wihch involves eliminiating an
individual's damaged or defective hematopoietic and immune system by
chemotherapy and/or radiotherapy and replacing it wit stem cells
from anther individual or with a previously harvested protion of the
individual's own hematopoietic stem cells. |
| Bone Marrow transplantation |
BMT |
Collection of hematopoietic stem cells from bone marrw
under general anesthesia. |
| Peripheral blood stem cell transplantion |
PBSCT |
Collection of hematopoietic stem cells from peripheral
blood using cell separator machines. |
| Apheresis |
Pheresis |
A procedure performed on a donor or patient in which
blood is withdrawn from the person and is separted ex-vivo into some
or all its component parts, of which some are retained fir donation
or therapeutic purposes with the remainder returend to the person. |
| Human
leucocyte antigens |
HLA |
Proteins
foud on the surface of many cells which have the ability to
distinguish foreign tissue from self.Each individual expresses a
group of antigens that differentiates that individual from
others.The primary focus of donor identification for allogeneic
transplant us the determination of HLA compatibility (HLA typing). |
| Allogeneic
BMT |
Allo-BMT |
A
type of BMT in which hematopoietic stem cells are obtained
from another person which may be:
- HLA-matched
sibling donor
- HLA-matched
unrelated donor.
- Partially
HLA-matched family member.
|
| Syngeneic
BMT |
Syn-BMT |
A
type of BMT in which hematopoietic stem cells are obtained from an
identical twin. |
| Autologous
BMT |
ABMT |
- Patient's own
hematopoietic stem cells are collected befor administration of
gigh dose chemotherapy.
- the stored cells
are re-infused after HSCT for enhancement of bone
marrowrecovery.
|
| Mobilization |
t |
The
use of hematopoietic groth factp factors with or without
chemotherapy to release marrow stem cells into the peripheral blood
which can be collected from the veins of the patient or donor. |
| Leukapheresis |
Leucapheresis |
A
procedure in which large numbers of leukocytes are harvested
from the peripheral blood of donor or a patient. |
| Dose
intensive therapy |
Conditioning
(pereparative) regimen. |
Treatment
that that produces absolute granulocytopenia of at least several
days duration in all patients. |
| Dose
intensity |
t |
The
amount of drug delivered per unit time (expressed as fof
example;mg/m2/w) regardless of schedule or route of administration. |
| Standard
dose |
t |
Doses
used by investigators reporting the first clinical trials with a
particular regimen.,or it may be the dose of drugs used by the most
influential clinical investigators. |
| High
dose chemotherapy |
HDC |
Doses
above the standerd dose range(3x or more than conventional dose). |
| Myeloablative
therapy |
t |
Extremely
high doses of chemotherapy with or without radiation that teqire
stem cell [bone Marrow (BM)or peripheral blood stem cells (PBSC)]
REPLACEMENT. |
| Graft-ve-leukemia
effect. |
GVL |
During
allogeneic transplantation,The donor immune system can help to
eradicate the patient's leukemia. |
| Non-myeloablative
therapy |
Mini-
trnsplantation |
Conditioning
regimens which do not completely destory the host bone marrow. The
aim of this minitransplants is to use enough immunosuppression to
allow donor stem cells to engraft. Such regimens rely heavily on the
ability of the GVL effect to cure the underlying malignant disease. |
| Graft-versus-host-disease |
GVHD |
A
syndrome in which the immunocompetent T cells and NK cells in the
donor graft recognize host antigens as foreign targets and mediate a
reaction. |
| Acute
graft-versus-host-diseae |
cGVHD |
A
late from of GVHD whivh occurs usually>100 days after transplant.
This syndrome resmbles connective tissue disorderss like
scleroderma. The target organs are more widespead thane aGVHD. |
| Graft
rejection |
Failure
to engraft |
Donor
cells fial to regenerate within the recipient. |
| Veno-occlusive
disease. |
VOD |
Obliteration
of terminal hepatic venules and small lobular veins, resulting in
acute liver congestion.it is caused by hepatotoxicity of
chemotherapy and/or radiotherapy used for conditioning therapy. |
| Purging |
Negative
selection |
Negative
selection methods in which an attempt is made to specifically remove
contaminating tumour cells from harvested stem cells. |
